Cart
sales@molnova.com
AG 494
CAS No. 133550-35-3
AG 494( AG-494 | AG 494 | AG494 | Tyrphostin AG-494. )
Catalog No. M17249 CAS No. 133550-35-3
AG-494 is an inhibitor of epidermal growth factor receptor kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
|
| 10MG | 82 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | 370 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAG 494
-
NoteResearch use only, not for human use.
-
Brief DescriptionAG-494 is an inhibitor of epidermal growth factor receptor kinase.
-
DescriptionAG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells
-
In VitroIn DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells.AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
-
In Vivo——
-
SynonymsAG-494 | AG 494 | AG494 | Tyrphostin AG-494.
-
PathwayImmunology/Inflammation
-
TargetTLR
-
RecptorEGFR
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number133550-35-3
-
Formula Weight280.28
-
Molecular FormulaC16H12N2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (356.79 mM)
-
SMILESc1ccc(cc1)NC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N
-
Chemical Name2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gazit, A. et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry 32(10), 2344-2352 (1989).
molnova catalog
related products
-
BBIQ
BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and it is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1 nM for human TLR7.
-
ABR-238901
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).
-
Sparstolonin B
Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities.
